RAF Typhoon FGR4s have operated alongside France's air force in a coordinated attack on an hidden munitions depot in Syrian territory operated by the Islamic State group (IS), according to the British defence ministry.
The location, located using surveillance, was assessed as housing weapons and explosive materials, the statement said, and was located in hills just above the ancient city of Palmyra in the heart of Syria.
"The RAF jets used precision-guided Paveway IV munitions to strike a several access tunnels leading to the depot... early reports indicate the objective was successfully hit," the ministry announced.
There was no evidence of any civilian casualties in the attack late on Saturday and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were supported by a Voyager tanker plane.
IS - also known as the so-called Islamic State - imposed extremist governance over large swathes of Iraq and Syria until 2019.
"This strike demonstrates British leadership, and commitment to operate in unison with allied nations, to stamp out any resurgence of the terrorist group and their violent and radical beliefs in the region," UK Defence Secretary John Healey remarked.
RAF aircraft have performed surveillance missions over Syrian airspace to "deter any attempted comeback" of the group after its defeat at the Baghuz confrontation in 2019, the ministry said.
"I want to thank every member of British forces participating in this strike for their skill and their valour," Healey commented. "They were among a great many British troops stationed over Christmas and New Year. This operation, to take out dangerous terrorists who threaten our way of life, highlights how British military are prepared to act, all year round, ensuring Britain's security domestically and influential overseas."
In December, the American forces carried out what it termed a "massive strike" targeting Daesh sites in Syria, following an attack claimed the lives of two American soldiers and a civilian interpreter in the Palmyra area.
The U.N. says Islamic State still has between 5,000 and 7,000 combatants in both countries.